Details

Autor(en) / Beteiligte

• Greene, John D W
• Hodges, John R
• Ironside, James W
• Warlow, Charles P

Titel

Progressive aphasia with rapidly progressive dementia in a 49 year old woman

Ist Teil von

• Journal of neurology, neurosurgery and psychiatry, 1999-02, Vol.66 (2), p.238-243

Ort / Verlag

London: BMJ Publishing Group Ltd

Erscheinungsjahr

1999

Quelle

MEDLINE

Beschreibungen/Notizen

• The following blood tests were normal: full blood count, erythrocyte sedimentation rate, B12, folate, urea and electrolytes, glucose, liver function, thyroid function, lipids, serum immunoglobulins, vanereal disease research laboratory test, and serum copper. In Japan, where the average survival of patients with Creutzfeldt-Jakob disease is much longer than in the United Kingdom, cerebral atrophy is common, with brain weights not infrequently reduced to 800-900 g. Dr Knight (National CJD Surveillance Unit, Edinburgh)-We rarely see atrophy on MRI in Creutzfeldt-Jakob disease. Sporadic Creutzfeldt-Jakob disease Pathological diagnosis Creutzfeldt-Jakob disease Comment Primary progressive aphasia may sometimes remain an isolated phenomenon, without accompanying non-linguistic cognitive deficits. 1 3 19 The issue of whether all patients with progressive aphasia eventually develop more generalised dementia remains controversial, but there is little doubt that, in many instances, progressive language disorder is the harbinger of dementia. [...]this presentation is not specific for any one disease 20 ; patients with Pick disease, 8-11 Alzheimer's disease, 4-7 and Creutzfeldt-Jakob disease 12 13 21 have been described with progressive aphasia.