Details

Autor(en) / Beteiligte

• Maher, E R
• Brueton, L A
• Bowdin, S C
• Luharia, A
• Cooper, W
• Cole, T R
• Macdonald, F
• Sampson, J R
• Barratt, C L
• Reik, W
• Hawkins, M M

Titel

Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)

Ist Teil von

• Journal of medical genetics, 2003-01, Vol.40 (1), p.62-64

Ort / Verlag

England: BMJ Publishing Group Ltd

Erscheinungsjahr

2003

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To test the significance of the observed and expected frequencies we used a Poisson approximation to the binomial distribution and obtained a two tailed p value of 0.018. [...]the observed frequency (n=6) of IVF and ICSI births in the BWS series is significantly greater than the expected (1.7252), with an associated 95% confidence interval on the excess risk of 1.5, 8.8. Had such data been available, then this would have very probably reduced the expected number of BWS births after IVF or ICSI, as the birth rate in the general population has been declining since 1989 and the annual number of ART births before 1995 would have been less than during the five years included in the comparison. [...]our comparison is likely to be conservative in relation to calendar year.