Science (American Association for the Advancement of Science), 2006-04, Vol.312 (5772), p.452-454
2006
Details
- Autor(en) / Beteiligte
- Titel
- RNA Interference Directs Innate Immunity Against Viruses in Adult Drosophila
- Ist Teil von
- Science (American Association for the Advancement of Science), 2006-04, Vol.312 (5772), p.452-454
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Innate immunity against bacterial and fungal pathogens is mediated by Toll and immune deficiency (Imd) pathways, but little is known about the antiviral response in DROSOPHILA: Here, we demonstrate that an RNA interference pathway protects adult flies from infection by two evolutionarily diverse viruses. Our work also describes a molecular framework for the viral immunity, in which viral double-stranded RNA produced during infection acts as the pathogen trigger whereas Drosophila Dicer-2 and Argonaute-2 act as host sensor and effector, respectively. These findings establish a Drosophila model for studying the innate immunity against viruses in animals.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1125694Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1509097
- Format
- –
- Schlagworte
- Adults, Animals, Antivirals, Argonaute Proteins, Biological and medical sciences, Cell Line, Cricket paralysis virus, disease resistance, double-stranded RNA, Drosophila, Drosophila melanogaster, Drosophila melanogaster - embryology, Drosophila melanogaster - genetics, Drosophila melanogaster - immunology, Drosophila melanogaster - virology, Drosophila Proteins - genetics, Drosophila Proteins - metabolism, Drosophila Proteins - physiology, Embryo, Nonmammalian - immunology, Embryo, Nonmammalian - virology, Embryos, Escherichia coli - physiology, Flock house virus, Fundamental and applied biological sciences. Psychology, gene silencing, Immunity, Immunity, Innate, Immunology, Infections, Innate immunity, insect diseases, Insect Viruses - genetics, Insect Viruses - physiology, Insects, Microbiology, Micrococcus luteus - physiology, Mutation, Nodaviridae - physiology, Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains, Ribonuclease III, Ribonucleic acid, RNA, RNA Helicases - genetics, RNA Helicases - metabolism, RNA Interference, RNA Viruses - genetics, RNA Viruses - physiology, RNA, Double-Stranded - metabolism, RNA, Small Interfering - metabolism, RNA, Viral - genetics, RNA, Viral - metabolism, RNA-Binding Proteins - genetics, RNA-Binding Proteins - physiology, RNA-Induced Silencing Complex - genetics, RNA-Induced Silencing Complex - physiology, Signal Transduction, Small interfering RNA, Toll-Like Receptors - physiology, Tolls, Transfection, Virology, Virus Replication, Viruses