Details

Autor(en) / Beteiligte

• Gold, Diane R.
• Willwerth, Ben M.
• Tantisira, Kelan G.
• Finn, Patricia W.
• Schaub, Bianca
• Perkins, David L.
• Tzianabos, Arthur
• Ly, Ngoc P.
• Schroeter, Christian
• Gibbons, Fiona
• Campos, Hannia
• Oken, Emily
• Gillman, Matthew W.
• Palmer, Lyle J.
• Ryan, Louise M.
• Weiss, Scott T.

Titel

Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ

Ist Teil von

• Journal of Allergy and Clinical Immunology, 2006-04, Vol.117 (4), p.931-938

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

2006

Link zum Volltext

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. We evaluated whether cord blood fatty acid levels were related to neonatal immune responses and whether n-3 and n-6 PUFA responses differed. We examined the relation of cord blood plasma n-3 and n-6 PUFAs (n = 192) to antigen- and mitogen-stimulated cord blood lymphocyte proliferation (n = 191) and cytokine (IL-13 and IFN-γ; n = 167) secretion in a US birth cohort. Higher levels of n-6 linoleic acid were correlated with higher IL-13 levels in response to Bla g 2 (cockroach, P = .009) and Der f 1 (dust mite, P = .02). Higher n-3 EPA and n-6 AA levels were each correlated with reduced lymphocyte proliferation and IFN-γ levels in response to Bla g 2 and Der f 1 stimulation. Controlling for potential confounders, EPA and AA had similar independent effects on reduced allergen-stimulated IFN-γ levels. If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-γ levels were 90% lower ( P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Reduced AA/EPA ratio was associated with reduced allergen-stimulated IFN-γ level. Increased levels of fetal n-3 EPA and n-6 AA might have similar effects on attenuation of cord blood lymphocyte proliferation and IFN-γ secretion. The implications of these findings for allergy or asthma development are not yet known.