Details

Autor(en) / Beteiligte

• Nanda, Indrajit
• Hornung, Ute
• Kondo, Mariko
• Schmid, Michael
• Schartl, Manfred

Titel

Common Spontaneous Sex-Reversed XX males of the Medaka Oryzias latipes

Ist Teil von

• Genetics (Austin), 2003-01, Vol.163 (1), p.245-251

Ort / Verlag

United States: Genetics Soc America

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• In the medaka, a duplicated version of the dmrt1 gene, dmrt1bY, has been identified as a candidate for the master male sex-determining gene on the Y chromosome. By screening several strains of Northern and Southern medaka we identified a considerable number of males with normal phenotype and uncompromised fertility, but lacking dmrt1bY. The frequency of such males was >10% in some strains and zero in others. Analysis for the presence of other Y-linked markers by FISH analysis, PCR, and phenotype indicated that their genotype is XX. Crossing such males with XX females led to a strong female bias in the offspring and also to a reappearance of XX males in the following generations. This indicated that the candidate male sex-determining gene dmrt1bY may not be necessary for male development in every case, but that its function can be taken over by so far unidentified autosomal modifiers.