Gut, 1988-05, Vol.29 (5), p.580-587
1988
Details
- Autor(en) / Beteiligte
- Titel
- Lactosylceramide in inflammatory bowel disease: a biochemical study
- Ist Teil von
- Gut, 1988-05, Vol.29 (5), p.580-587
- Ort / Verlag
- London: BMJ Publishing Group Ltd and British Society of Gastroenterology
- Erscheinungsjahr
- 1988
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- A simple technique for isolating lipids from small pieces of tissue was applied to mucosal biopsies and samples of resected intestine from patients with inflammatory bowel disease. Scanning densitometry of two dimensional chromatograms showed increased concentrations of the membrane associated glycosphingolipid lactosylceramide in Crohn's disease, on comparison with ulcerative colitis (p less than 0.01), or controls (p less than 0.01). This indicates either that normal glycosphingolipid metabolism is altered, or that a novel source of lactosylceramide is present in the inflamed mucosa of patients with Crohn's disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0017-5749eISSN: 1468-3288DOI: 10.1136/gut.29.5.580Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1433632
- Format
- –
- Schlagworte
- Adolescent, Adult, Antigens, CD, Biological and medical sciences, Child, Chromatography, Thin Layer, Colitis, Ulcerative - metabolism, Crohn Disease - metabolism, Densitometry, Female, Gastroenterology. Liver. Pancreas. Abdomen, Glycosphingolipids - analysis, Humans, Intestinal Mucosa - analysis, Lactosylceramides, Male, Medical sciences, Other diseases. Semiology, Phosphatidylethanolamines - analysis, Stomach. Duodenum. Small intestine. Colon. Rectum. Anus