Details

Autor(en) / Beteiligte

• HESKETH, J.E.
• LOUDON, J.B.
• READING, H.W.
• GLEN, A.I.M.

Titel

THE EFFECT OF LITHIUM TREATMENT ON ERYTHROCYTE MEMBRANE ATPase ACTIVITIES AND ERYTHROCYTE ION CONTENT

Ist Teil von

• British journal of clinical pharmacology, 1978-04, Vol.5 (4), p.323-329

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1978

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• 1 ATPase activities were studied in erythrocyte membranes prepared from blood of patients suffering from affective disorders. 2 Long‐term (9–12 months) administration of lithium led to an increase in the erythrocyte membrane Na/K ATPase activity (54%) when studied on an age and sex matched basis or when the patients were studied before and after treatment. The Mg ATPase activity was also increased (38%) but there was no consistent effect of lithium treatment on Ca stimulated ATPase activity in the membranes. It is suggested that the effect of lithium treatment on Na/K ATPase was due to recovery of the patients rather than an effect of the drug. 3 MgATPase activity increased regardless of clinical condition. Short‐term lithium treatment (2–4 weeks) led to increased Mg ATPase activity (43%). These results suggest that lithium treatment itself causes an increase in Mg ATPase activity and that this effect is not dependent on changes in protein synthesis. 4 Lithium treatment (long‐term) increased the erythrocyte sodium content by 15%. No effect on plasma sodium, magnesium, potassium or erythrocyte magnesium and potassium was observed.