British journal of clinical pharmacology, 1985-09, Vol.20 (3), p.238-240
1985
Details
- Autor(en) / Beteiligte
- Titel
- The effects of sucralfate upon phenytoin absorption in man
- Ist Teil von
- British journal of clinical pharmacology, 1985-09, Vol.20 (3), p.238-240
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 1985
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek (Open access)
- Beschreibungen/Notizen
- The possible influence of sucralfate on phenytoin absorption was investigated in a double‐blind, placebo controlled study. Concomitant administration of 1 g sucralfate reduced the absorption of 300 mg phenytoin capsules by 20% as measured by the area under the curve from 0‐48 h. This could be of significance in epileptic patients stabilised on phenytoin in whom sucralfate is used in ulcer treatment.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-5251eISSN: 1365-2125DOI: 10.1111/j.1365-2125.1985.tb05067.xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1400695
- Format
- –
- Schlagworte
- Adult, Aluminum - pharmacology, Anticonvulsants. Antiepileptics. Antiparkinson agents, Biological and medical sciences, Biological Availability, Double-Blind Method, Drug Interactions, Humans, Intestinal Absorption - drug effects, Kinetics, Male, Medical sciences, Neuropharmacology, Pharmacology. Drug treatments, Phenytoin - metabolism, Sucralfate