British journal of clinical pharmacology, 1985-08, Vol.20 (2), p.133-136
1985
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Details
- Autor(en) / Beteiligte
- Titel
- L‐643.441: an H2‐receptor antagonist with potent and long‐lasting effects in man
- Ist Teil von
- British journal of clinical pharmacology, 1985-08, Vol.20 (2), p.133-136
- Ort / Verlag
- Oxford, UK: Blackwell Publishing Ltd
- Erscheinungsjahr
- 1985
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Submaximal dose pentagastrin tests conducted in normal male volunteers with L‐643.441, a novel histamine H2‐receptor antagonist, indicate that it is a potent and long‐acting inhibitor of gastric acid secretion. The effect appears dose‐dependent and single doses of 50 mg are sufficient to reduce secretory potential by at least 50% when examined 24 h after drug administration. No adverse effects attributable to treatment were observed.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-5251eISSN: 1365-2125DOI: 10.1111/j.1365-2125.1985.tb05043.xTitel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1400675
- Format
- –
- Schlagworte
- Adult, Biological and medical sciences, Chemical Phenomena, Chemistry, Digestive system, Dose-Response Relationship, Drug, Gastric Acid - metabolism, Histamine H2 Antagonists, Humans, Male, Medical sciences, Pentagastrin - antagonists & inhibitors, Pharmacology. Drug treatments, Thiadiazoles - pharmacology, Time Factors