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Effects of Helicobacter pylori on histamine and carbachol stimulated acid secretion by human parietal cells
Ist Teil von
Gut, 1994-06, Vol.35 (6), p.755-757
Ort / Verlag
London: BMJ Publishing Group Ltd and British Society of Gastroenterology
Erscheinungsjahr
1994
Quelle
MEDLINE
Beschreibungen/Notizen
Helicobacter pylori (H pylori) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiological pathways by which H pylori interacts with acid secretion are still unclear. The effects of H pylori on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submaximal concentrations of histamine or carbachol and incubated with sonicates of different H pylori strains. Omeprazole and sonicates of Campylobacter jejuni served as positive and negative controls, respectively. Two of four H pylori strains reduced hydrochloric acid sequestration within the parietal cells significantly and in a dose dependent manner in up to 80%. Interaction with acid secretion may therefore constitute a factor contributing to a distinct pathogenicity of H pylori strains.