RNA (Cambridge), 2004-11, Vol.10 (11), p.1702-1703
2004
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Novel application of sRNA: stimulation of ribosomal frameshifting
- Ist Teil von
- RNA (Cambridge), 2004-11, Vol.10 (11), p.1702-1703
- Ort / Verlag
- United States: Copyright 2004 by RNA Society
- Erscheinungsjahr
- 2004
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Small RNAs play an important role in regulation of gene expression in eukaryotic and eubacterial cells by modulating gene expression both at the level of transcription and translation. Here, we show that short complementary RNAs can also affect gene expression by stimulating ribosomal frameshifting in vitro. This finding has important implications for understanding the process of ribosomal frameshifting and for the potential application of small RNAs in the treatment of diseases that are due to frameshift mutations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1355-8382eISSN: 1469-9001DOI: 10.1261/rna.7139704Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1370657
- Format
- –
- Schlagworte
- Base Pairing, Codon, Codon, Terminator, Enhancer Elements, Genetic, Frameshifting, Ribosomal - genetics, Gene Expression Regulation, Letter to the Editor, Oligonucleotides - metabolism, Open Reading Frames, Protein Biosynthesis, Recombinant Fusion Proteins - metabolism, Ribosomes - metabolism, RNA Interference, RNA, Messenger - genetics, RNA, Messenger - metabolism, RNA, Small Interfering - metabolism, Thermodynamics, Transcription, Genetic