Details

Autor(en) / Beteiligte

• Gjesdal, K.
• Klemsdal, TO
• Rykke, EO
• Bredesen, JE

Titel

Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch

Ist Teil von

• British journal of clinical pharmacology, 1991-05, Vol.31 (5), p.560-562

Ort / Verlag

Oxford, UK: Blackwell Publishing Ltd

Erscheinungsjahr

1991

Quelle

MEDLINE

Beschreibungen/Notizen

• Ten volunteers carried a 10 mg 24 h −1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN‐concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate‐concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.