Science (American Association for the Advancement of Science), 2005-07, Vol.309 (5731), p.148-150
- Maione, Domenico
- Margarit, Immaculada
- Rinaudo, Cira D
- Masignani, Vega
- Mora, Marirosa
- Scarselli, Maria
- Tettelin, Hervé
- Brettoni, Cecilia
- Iacobini, Emilia T
- Rosini, Roberto
- D'Agostino, Nunzio
- Miorin, Lisa
- Buccato, Scilla
- Mariani, Massimo
- Galli, Giuliano
- Nogarotto, Renzo
- Dei, Vincenzo Nardi
- Vegni, Filipo
- Fraser, Claire
- Mancuso, Giuseppe
- Teti, Giuseppe
- Madoff, Lawrence C
- Paoletti, Lawrence C
- Rappuoli, Rino
- Kasper, Dennis L
- Telford, John L
- Grandi, Guido
2005
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Maione, Domenico
- Margarit, Immaculada
- Rinaudo, Cira D
- Masignani, Vega
- Mora, Marirosa
- Scarselli, Maria
- Tettelin, Hervé
- Brettoni, Cecilia
- Iacobini, Emilia T
- Rosini, Roberto
- D'Agostino, Nunzio
- Miorin, Lisa
- Buccato, Scilla
- Mariani, Massimo
- Galli, Giuliano
- Nogarotto, Renzo
- Dei, Vincenzo Nardi
- Vegni, Filipo
- Fraser, Claire
- Mancuso, Giuseppe
- Teti, Giuseppe
- Madoff, Lawrence C
- Paoletti, Lawrence C
- Rappuoli, Rino
- Kasper, Dennis L
- Telford, John L
- Grandi, Guido
- Titel
- Identification of a Universal Group B Streptococcus Vaccine by Multiple Genome Screen
- Ist Teil von
- Science (American Association for the Advancement of Science), 2005-07, Vol.309 (5731), p.148-150
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2005
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- Group B Streptococcus (GBS) is a multiserotype bacterial pathogen representing a major cause of life-threatening infections in newborns. To develop a broadly protective vaccine, we analyzed the genome sequences of eight GBS isolates and cloned and tested 312 surface proteins as vaccines. Four proteins elicited protection in mice, and their combination proved highly protective against a large panel of strains, including all circulating serotypes. Protection also correlated with antigen accessibility on the bacterial surface and with the induction of opsonophagocytic antibodies. Multigenome analysis and screening described here represent a powerful strategy for identifying potential vaccine candidates against highly variable pathogens.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075, 1095-9203eISSN: 1095-9203DOI: 10.1126/science.1109869Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1351092
- Format
- –
- Schlagworte
- Algorithms, Animals, Animals, Newborn, Antibodies, Antibodies, Bacterial - biosynthesis, Antigens, Antigens, Bacterial - genetics, Antigens, Bacterial - immunology, Antigens, Surface - genetics, Antigens, Surface - immunology, Bacteria, Bacterial Proteins - immunology, Bacteriology, Biological and medical sciences, Coding, Complications and side effects, Computational Biology, Dosage and administration, Female, Fluorescence, Fundamental and applied biological sciences. Psychology, Genetic screening, genome, Genome, Bacterial, Genomes, Genomics, House mouse, Humans, Immunity, Maternally-Acquired, Mice, Mice as laboratory animals, Microbiology, Neonates, Neutrophils, Neutrophils - immunology, nucleotide sequences, Opsonin Proteins, Pathogens, Phagocytosis, Prophylaxis, screening, serotypes, Serotyping, Streptococcal Infections - immunology, Streptococcal Infections - microbiology, Streptococcal Infections - prevention & control, Streptococcal Vaccines - immunology, Streptococcus, Streptococcus agalactiae, Streptococcus agalactiae - classification, Streptococcus agalactiae - genetics, Streptococcus agalactiae - immunology, Studies, surface proteins, Vaccination, Vaccines, Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies