Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Circulatory effects of a depilatory dose of mouse epidermal growth factor in sheep
Ist Teil von
The Journal of physiology, 1988-09, Vol.403 (1), p.27-39
Ort / Verlag
Oxford: The Physiological Society
Erscheinungsjahr
1988
Quelle
MEDLINE
Beschreibungen/Notizen
1. Haemodynamic parameters and tissue blood flow rates were measured in two groups of five sheep infused I.V. for 24 h with
either saline or 128.6 micrograms mouse epidermal growth factor (mEGF) kg-1 body weight. Measurements were made preinfusion
and at +3, +12, +24, +27 and +48 h. We wished to assess relationships between blood flow rates and known functional changes
in various organs during EGF treatment, especially any relationship between skin blood flow rate and the known depilatory
effects of the protein in sheep. 2. Cardiac output increased and total peripheral resistance and mean arterial pressure decreased
during and after infusion in the mEGF-treated group relative to the control group. 3. The greatest increase in blood flow
rates occurred in woolled skin (+500%) during mEGF infusion, a result which in itself may have been disparate with the known
depilatory effects of EGF. The mucosas of the alimentary tract (except abomasum) and the submaxillary and sublingual salivary
glands also showed vasodilatation. 4. There were short-term increases in pituitary and adrenal gland blood flow that may have
been associated with the corticotrophin-releasing factor properties of EGF. Flow in the thyroids showed the greatest increase
post-infusion when thyroid hormone metabolism may have been reverting to normal. Blood flow rates decreased in the pancreas
and perirenal fat. 5. Our general conclusion was that mEGF had specific vasodilator effects in the skin, the thyroid, submaxillary
and sublingual glands and the mucosas of most of the alimentary tract.