Details

Autor(en) / Beteiligte

• Abkevich, Victor
• Camp, Nicola J.
• Hensel, Charles H.
• Neff, Chris D.
• Russell, Deanna L.
• Hughes, Dana C.
• Plenk, Agnes M.
• Lowry, Michael R.
• Richards, R. Lynn
• Carter, Catherine
• Frech, Georges C.
• Stone, Steven
• Rowe, Kerry
• Chau, Chi Ai
• Cortado, Kathleen
• Hunt, Angelene
• Luce, Karanina
• O’Neil, Gayanne
• Poarch, Jeff
• Potter, Jennifer
• Poulsen, Gregg H.
• Saxton, Heidi
• Bernat-Sestak, Michelle
• Thompson, Victor
• Gutin, Alexander
• Skolnick, Mark H.
• Shattuck, Donna
• Cannon-Albright, Lisa

Titel

Predisposition Locus for Major Depression at Chromosome 12q22-12q23.2

Ist Teil von

• American journal of human genetics, 2003-12, Vol.73 (6), p.1271-1281

Ort / Verlag

Chicago, IL: Elsevier Inc

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Major depression disorder is a common psychiatric disease with a major economic impact on society. In many cases, no effective treatment is available. The etiology of major depression is complex, but it is clear that the disease is, to a large extent, determined genetically, especially among individuals with a familial history of major depression, presumably through the involvement of multiple predisposition genes in addition to an environmental component. As a first step toward identification of chromosomal loci contributing to genetic predisposition to major depression, we have conducted a genomewide scan by using 628 microsatellite markers on 1,890 individuals from 110 Utah pedigrees with a strong family history of major depression. We identified significant linkage to major depression in males at marker D12S1300 (multipoint heterogeneity LOD score 4.6; P=.00003 after adjustment for multiple testing). With additional markers, the linkage evidence became highly significant, with the multipoint heterogeneity LOD score at marker D12S1706 increasing to 6.1 ( P=.0000007 after adjustment for multiple testing). This study confirms the presence of one or more genes involved in psychiatric diseases on the q arm of chromosome 12 and provides strong evidence for the existence of a sex-specific predisposition gene to major depression at 12q22-q23.2.