Details

Autor(en) / Beteiligte

• Hande, M. Prakash
• Azizova, Tamara V.
• Geard, Charles R.
• Burak, Ludmilla E.
• Mitchell, Catherine R.
• Khokhryakov, Valentin F.
• Vasilenko, Evgeny K.
• Brenner, David J.

Titel

Past Exposure to Densely Ionizing Radiation Leaves a Unique Permanent Signature in the Genome

Ist Teil von

• American journal of human genetics, 2003-05, Vol.72 (5), p.1162-1170

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2003

Quelle

MEDLINE

Beschreibungen/Notizen

• Speculation has long surrounded the question of whether past exposure to ionizing radiation leaves a unique permanent signature in the genome. Intrachromosomal rearrangements or deletions are produced much more efficiently by densely ionizing radiation than by chemical mutagens, x-rays, or endogenous aging processes. Until recently, such stable intrachromosomal aberrations have been very hard to detect, but a new chromosome band painting technique has made their detection practical. We report the detection and quantification of stable intrachromosomal aberrations in lymphocytes of healthy former nuclear-weapons workers who were exposed to plutonium many years ago. Even many years after occupational exposure, more than half the blood cells of the healthy plutonium workers contain large (>6 Mb) intrachromosomal rearrangements. The yield of these aberrations was highly correlated with plutonium dose to the bone marrow. The control groups contained very few such intrachromosomal aberrations. Quantification of this large-scale chromosomal damage in human populations exposed many years earlier will lead to new insights into the mechanisms and risks of cytogenetic damage.