Details

Autor(en) / Beteiligte

• Whitham, S E
• Murphy, G
• Angel, P
• Rahmsdorf, H J
• Smith, B J
• Lyons, A
• Harris, T J
• Reynolds, J J
• Herrlich, P
• Docherty, A J

Titel

Comparison of human stromelysin and collagenase by cloning and sequence analysis

Ist Teil von

• Biochemical journal, 1986-12, Vol.240 (3), p.913-916

Ort / Verlag

England

Erscheinungsjahr

1986

Quelle

MEDLINE

Beschreibungen/Notizen

• A comparison of the cDNA-derived amino acid sequences of human stromelysin and collagenase with the N-terminal sequences of purified enzymes reveals that these metalloproteinases are highly conserved and that they are secreted as proenzymes. A putative zinc-binding site was identified by its homology with the zinc-chelating sequence of thermolysin. These sequences permitted the identification of: transin, a protein induced in rat fibroblasts either exposed to growth factors or transformed by oncogenic viruses, as the rat homologue of stromelysin, and XHF1, a protein induced in human fibroblasts after treatment with tumourigenic agents, as collagenase.