Details

Autor(en) / Beteiligte

• Dočekal, Vojtěch
• Niderer, Yaroslava
• Kurčina, Adam
• Císařová, Ivana
• Veselý, Jan

Titel

Regio- and Enantioselective N‑Heterocyclic Carbene-Catalyzed Annulation of Aminoindoles Initiated by Friedel–Crafts Alkylation

Ist Teil von

• Organic letters, 2024-08, Vol.26 (33), p.6993-6998

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2024

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Chiral indoles annulated on the benzene ring are unique and significant in natural and medicinal compounds. However, accessing these enantioenriched molecules has often been overlooked. The present study introduces an organocatalytic protocol to access these compounds efficiently, demonstrated by substrate scope, functional group tolerance, and using only 1 mol % of a chiral conjugated acid catalyst. Additionally, the study explores regioselectivity, gram-scale reactions, and follow-up transformations, underscoring the method’s potential.