Details

Autor(en) / Beteiligte

• Chen, Yan
• Zhang, Zhaohui
• Chen, Zhijian
• Jiang, Shiqing
• Reheman, Aikebaier
• Ouyang, Yifan
• Yu, Bo
• Chen, Qiuyan
• Wei, Dingtai
• Farmany, Abbas

Titel

Iron gallic acid biomimetic nanoparticles for targeted magnetic resonance imaging

Ist Teil von

• PloS one, 2024-07, Vol.19 (7), p.e0306142

Ort / Verlag

San Francisco: Public Library of Science

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Developing T.sub.1 -weighted magnetic resonance imaging (MRI) contrast agents with enhanced biocompatibility and targeting capabilities is crucial owing to concerns over current agents' potential toxicity and suboptimal performance. Drawing inspiration from "biomimetic camouflage," we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)-GA nanoparticles (NPs) proved effective as a T.sub.1 -weighted MRI contrast agent. T98G CM-coated Fe-GA NPs demonstrated improved homotypic glioma targeting, validated through Prussian blue staining and in vitro MRI. This biomimetic camouflage strategy holds promise for the development of targeted theranostic agents in a safe and effective manner.