Details

Autor(en) / Beteiligte

• Bendová, Barbora
• Bímová, Barbora Vošlajerová
• Čížková, Dagmar
• Daniszová, Kristina
• Ďureje, Ľudovít
• Hiadlovská, Zuzana
• Macholán, Miloš
• Piálek, Jaroslav
• Schmiedová, Lucie
• Kreisinger, Jakub

Titel

The strength of gut microbiota transfer along social networks and genealogical lineages in the house mouse

Ist Teil von

• FEMS microbiology ecology, 2024-05, Vol.100 (6)

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• The gut microbiota of vertebrates is acquired from the environment and other individuals, including parents and unrelated conspecifics. In the laboratory mouse, a key animal model, inter-individual interactions are severely limited and its gut microbiota is abnormal. Surprisingly, our understanding of how inter-individual transmission impacts house mouse gut microbiota is solely derived from laboratory experiments. We investigated the effects of inter-individual transmission on gut microbiota in two subspecies of house mice (Mus musculus musculus and M. m. domesticus) raised in a semi-natural environment without social or mating restrictions. We assessed the correlation between microbiota composition (16S rRNA profiles), social contact intensity (microtransponder-based social networks), and mouse relatedness (microsatellite-based pedigrees). Inter-individual transmission had a greater impact on the lower gut (colon and cecum) than on the small intestine (ileum). In the lower gut, relatedness and social contact independently influenced microbiota similarity. Despite female-biased parental care, both parents exerted a similar influence on their offspring's microbiota, diminishing with the offspring's age in adulthood. Inter-individual transmission was more pronounced in M. m. domesticus, a subspecies, with a social and reproductive network divided into more closed modules. This suggests that the transmission magnitude depends on the social and genetic structure of the studied population.