Details

Autor(en) / Beteiligte

• Xhima, Kristiana
• Ottoy, Julie
• Gibson, Erin
• Zukotynski, Katherine
• Scott, Christopher
• Feliciano, Ginelle J.
• Adamo, Sabrina
• Kuo, Phillip H.
• Borrie, Michael J.
• Chertkow, Howard
• Frayne, Richard
• Laforce, Robert
• Noseworthy, Michael D.
• Prato, Frank S.
• Sahlas, Demetrios J.
• Smith, Eric E.
• Sossi, Vesna
• Thiel, Alexander
• Soucy, Jean‐Paul
• Tardif, Jean‐Claude
• Goubran, Maged
• Black, Sandra E.
• Ramirez, Joel

Titel

Distinct spatial contributions of amyloid pathology and cerebral small vessel disease to hippocampal morphology

Ist Teil von

• Alzheimer's & dementia, 2024-05, Vol.20 (5), p.3687-3695

Ort / Verlag

United States: John Wiley and Sons Inc

Erscheinungsjahr

2024

Quelle

Wiley-Blackwell Journals

Beschreibungen/Notizen

• INTRODUCTION Cerebral small vessel disease (SVD) and amyloid beta (Aβ) pathology frequently co‐exist. The impact of concurrent pathology on the pattern of hippocampal atrophy, a key substrate of memory impacted early and extensively in dementia, remains poorly understood. METHODS In a unique cohort of mixed Alzheimer's disease and moderate–severe SVD, we examined whether total and regional neuroimaging measures of SVD, white matter hyperintensities (WMH), and Aβ, as assessed by 18F‐AV45 positron emission tomography, exert additive or synergistic effects on hippocampal volume and shape. RESULTS Frontal WMH, occipital WMH, and Aβ were independently associated with smaller hippocampal volume. Frontal WMH had a spatially distinct impact on hippocampal shape relative to Aβ. In contrast, hippocampal shape alterations associated with occipital WMH spatially overlapped with Aβ‐vulnerable subregions. DISCUSSION Hippocampal degeneration is differentially sensitive to SVD and Aβ pathology. The pattern of hippocampal atrophy could serve as a disease‐specific biomarker, and thus guide clinical diagnosis and individualized treatment strategies for mixed dementia.