The Journal of clinical investigation, 2024-05, Vol.134 (10), p.1-3
2024
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- Autor(en) / Beteiligte
- Titel
- Targeting arrhythmogenic macrophages: lessons learned from arrhythmogenic cardiomyopathy
- Ist Teil von
- The Journal of clinical investigation, 2024-05, Vol.134 (10), p.1-3
- Ort / Verlag
- United States: American Society for Clinical Investigation
- Erscheinungsjahr
- 2024
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiac condition characterized by cardiac remodeling and life-threatening ventricular arrhythmias. In this issue of the JCI, Chelko, Penna, and colleagues mechanistically addressed the intricate contribution of immune-mediated injury in ACM pathogenesis. Inhibition of nuclear factor κ-B (NF-κB) and infiltration of monocyte-derived macrophages expressing C-C motif chemokine receptor-2 (CCR2) alleviated the phenotypic ACM features (i.e., fibrofatty replacement, contractile dysfunction, and ventricular arrhythmias) in desmoglein 2-mutant (Dsg2mut/mut) mice. These findings pave the way for efficacious and targetable immune therapy for patients with ACM.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1558-8238, 0021-9738eISSN: 1558-8238DOI: 10.1172/JCI180482Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11093592
- Format
- –
- Schlagworte
- Animals, Arrhythmias, Cardiac - genetics, Arrhythmias, Cardiac - immunology, Arrhythmias, Cardiac - metabolism, Arrhythmias, Cardiac - pathology, Arrhythmogenic Right Ventricular Dysplasia - genetics, Arrhythmogenic Right Ventricular Dysplasia - metabolism, Arrhythmogenic Right Ventricular Dysplasia - pathology, Cardiac arrhythmia, Cardiomyocytes, Cardiomyopathies - genetics, Cardiomyopathies - immunology, Cardiomyopathies - metabolism, Cardiomyopathies - pathology, Cardiomyopathy, Cardiovascular disease, Chemokine receptors, Chemokines, Conflicts of interest, Cytokines, Desmoglein 2 - genetics, Desmoglein 2 - immunology, Desmoglein 2 - metabolism, Fibroblasts, Gene therapy, Genotype & phenotype, Heart, Humans, Inflammation, Leukocytes, Macrophages, Macrophages - immunology, Macrophages - metabolism, Macrophages - pathology, Mice, Monocyte chemoattractant protein 1, Monocytes, Muscle contraction, Mutation, Myocarditis, NF-kappa B - genetics, NF-kappa B - metabolism, NF-κB protein, Pathogenesis, Pathophysiology, Receptors, CCR2 - antagonists & inhibitors, Receptors, CCR2 - genetics, Receptors, CCR2 - metabolism, Roles, Ventricle