Details

Autor(en) / Beteiligte

• Munzarová, M
• Zemanová, D
• Kovarík, J
• Pacovský, Z
• Rejthar, A
• Bártek, J

Titel

Expression of HLA-DR antigens on tumour cells does not contribute to skin reactivity to autologous cholesteryl hemisuccinate (CHS)-treated tumour cells in patients with metastatic melanoma

Ist Teil von

• Cancer Immunology Immunotherapy, 1987-06, Vol.24 (3), p.272-274

Ort / Verlag

Germany: Springer-Verlag

Erscheinungsjahr

1987

Quelle

MEDLINE

Beschreibungen/Notizen

• Skin tests with autologous cholesteryl hemisuccinate (CHS)-treated and untreated cells were performed in ten metastatic melanoma patients. In the majority of cases evident reaction was noted with CHS-treated cells (9/10) while the reaction with untreated cells was mostly negative (7/10). Tumour cell suspensions used for skin tests were characterized for reactivity with monoclonal antibody TAL 1B5 detecting the HLA-DR alpha chain. There were no differences between CHS-treated and untreated cells with respect to HLA-DR expression and no correlation was found between grade of skin reaction to CHS-treated cells and the proportion of HLA-DR positive cells in the injected cell sample.