Details

Autor(en) / Beteiligte

• Fildes, J. E
• Shaw, S. M
• Williams, S. G
• Yonan, N

Titel

Potential immunologic effects of statins in cancer following transplantation

Ist Teil von

• Cancer Immunology, Immunotherapy, 2009-03, Vol.58 (3), p.461-467

Ort / Verlag

Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag

Erscheinungsjahr

2009

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• 3-hydroxy-3-methyglutaryl CoA reductase inhibitors (statins) are frequently used following organ transplantation and have well reported pleiotropic effects, including immunomodulation, which may be of benefit in preventing graft rejection. However, the immunomodulatory effects of statins on cell transformation and malignancy, combined with the immunologic processes and administration of immunosuppression are almost completely unknown. The administration of immunosuppression is well recognised as the main cause of cancer following transplantation, so the addition of an immunomodulatory agent should be associated with an increased incidence of cancer, as immune surveillance and response may be suppressed, allowing cellular transformation and proliferation combined with lack of recognition to occur. This hypothetical review attempts to delineate the mode of action of statins in terms of pro/anti-carcinogenic mechanisms, while considering graft rejection and the presence of immunosuppression.