Details

Autor(en) / Beteiligte

• Velamazán, Raúl
• López‐Guillén, Pablo
• Martínez‐Domínguez, Samuel J.
• Abad Baroja, Daniel
• Oyón, Daniel
• Arnau, Anna
• Ruiz‐Belmonte, Lara M.
• Tejedor‐Tejada, Javier
• Zapater, Raul
• Martín‐Vicente, Noelia
• Fernández‐Esparcia, Pedro José
• Julián Gomara, Ana Belén
• Sastre Lozano, Violeta
• Manzanares García, Juan José
• Chivato Martín‐Falquina, Irene
• Andrés Pascual, Laura
• Torres Monclus, Nuria
• Zaragoza Velasco, Natividad
• Rojo, Eukene
• Lapeña‐Muñoz, Berta
• Flores, Virginia
• Díaz Gómez, Arantxa
• Cañamares‐Orbís, Pablo
• Vinzo Abizanda, Isabel
• Marcos Carrasco, Natalia
• Pardo Grau, Laura
• García‐Rayado, Guillermo
• Millastre Bocos, Judith
• Garcia Garcia de Paredes, Ana
• Vaamonde Lorenzo, María
• Izagirre Arostegi, Arantzazu
• Lozada‐Hernández, Edgard Efrén
• Velarde‐Ruiz Velasco, José Antonio
• de‐Madaria, Enrique

Titel

Symptomatic gallstone disease: Recurrence patterns and risk factors for relapse after first admission, the RELAPSTONE study

Ist Teil von

• United European gastroenterology journal, 2024-04, Vol.12 (3), p.286-298

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2024

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Background Delayed cholecystectomy in patients with symptomatic gallstone disease is associated with recurrence. Limited data on the recurrence patterns and the factors that determine them are available. Objective We aimed to determine the pattern of relapse in each symptomatic gallstone disease (acute pancreatitis, cholecystitis, cholangitis, symptomatic choledocholithiasis, and biliary colic) and determine the associated factors. Methods RELAPSTONE was an international multicenter retrospective cohort study. Patients (n = 3016) from 18 tertiary centers who suffered a first episode of symptomatic gallstone disease from 2018 to 2020 and had not undergone cholecystectomy during admission were included. The main outcome was relapse‐free survival. Kaplan–Meier curves were used in the bivariate analysis. Multivariable Cox regression models were used to identify prognostic factors associated with relapses. Results Mean age was 76.6 [IQR: 59.7–84.1], and 51% were male. The median follow‐up was 5.3 months [IQR 2.1–12.4]. Relapse‐free survival was 0.79 (95% CI: 0.77–0.80) at 3 months, 0.71 (95% CI: 0.69–0.73) at 6 months, and 0.63 (95% CI: 0.61–0.65) at 12 months. In multivariable analysis, older age (HR = 0.57; 95% CI: 0.49–0.66), sphincterotomy (HR = 0.58, 95% CI: 0.49–0.68) and higher leukocyte count (HR = 0.79; 95% CI: 0.70–0.90) were independently associated with lower risk of relapse, whereas higher levels of alanine aminotransferase (HR = 1.22; 95% CI: 1.02–1.46) and multiple cholelithiasis (HR = 1.19, 95% CI: 1.05–1.34) were associated with higher relapse rates. Conclusion The relapse rate is high and different in each symptomatic gallstone disease. Our independent predictors could be useful for prioritizing patients on the waiting list for cholecystectomies.