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Identification and Evaluation of Pathogenic Genes ( traT, hly, aer, pap, and fimH ) and Antibiotic Resistance Genes ( blaTEM, blaSHV, and blaCTX ) in Escherichia coli in Patients Referred to Gonabad Hospitals, Iran
Ist Teil von
Reports of biochemistry and molecular biology, 2023-10, Vol.12 (3), p.465-475
Ort / Verlag
Iran: Varastegan Institute for Medical Sciences
Erscheinungsjahr
2023
Link zum Volltext
Quelle
Free E-Journal (出版社公開部分のみ）
Beschreibungen/Notizen
Urinary tract infection (UTI) is one of the common bacterial infections.
is the most common cause of UTI. In this research, the prevalence of several virulence factors and beta-lactam resistance genes was investigated.
One hundred
isolates were collected from patients' specimens with UTI referred to Allame-Bohlol Gonabadi hospital. Polymerase chain reaction (PCR) was performed to identify five pathogenic genes (
) and three antibiotic resistance genes (
).
The frequencies of
and
beta-lactamase genes among extended-spectrum-beta-lactamases (ESBLs) positive isolates were 11.1%, 48.1%, and 93.3%, respectively. A significant number of isolates were resistant to the most commonly used antibiotics.
Pathogenic genes may also increase the severity, progression, and expansion of urinary tract infections. Therefore, identifying these genes as critical controllers of illness can use for better manage the treatment.