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Background
Breast cancer (BC) is one of the most prevalent cancers that contribute to mortality among women worldwide. Despite contradictory findings, considerable evidence suggests that single nucleotide polymorphisms (SNPs) in the
FSCN1
and
HOTAIR
genes may have a causative impact on the development of BC. This case–control study was conducted to evaluate the association of genotype frequency in
FSCN1
rs852479, rs1640233, and
HOTAIR
rs920778 with susceptibility and prognosis of BC, as well as the impact of clinical stages and hormonal features.
Methods and results
FSCN1
(rs852479, rs1640233) and
HOTAIR
(rs920778) were genotyped using TaqMan real-time PCR assay in 200 BC patients and 200 cancer-free controls, all representing Egyptian women. Genotypic analyses in association with clinicopathological factors and disease risk were assessed. As a result, a significant association with BC risk was observed for CC genotype frequency of
FSCN1
rs852479 A > C (OR = 0.395, 95% CI 0.204–0.76,
p
-
value
= 0.005). However, no significant correlation was detected between the
FSCN1
rs1640233 C > T and
HOTAIR
rs920778 C > T polymorphic variants and susceptibility to BC. Interestingly, CC genotype of
FSCN1
rs1640233 was more likely to progress tumor size and lymph node invasion in BC cases (
p
-
value
= 0.04 and 0.02, respectively). Moreover, it was revealed that there was a non-significant correlation between the haplotype distributions of
FSCN1
rs852479 and rs1640233 and the probability of BC.
Conclusions
Based on the sample size and genetic characteristics of the subjects involved in the present study, our findings indicated that
FSCN1
rs852479 may contribute to BC susceptibility in a sample of the Egyptian population.