Details

Autor(en) / Beteiligte

• Wiegand, Ryan E
• Odiere, Maurice R
• Kinung'hi, Safari
• N'Goran, Eliézer K
• Mwinzi, Pauline
• Secor, W Evan

Titel

Age-group associations of schistosomiasis prevalence from trial data, Côte d'Ivoire, Kenya and the United Republic of Tanzania

Ist Teil von

• Bulletin of the World Health Organization, 2024-04, Vol.102 (4), p.265-275

Ort / Verlag

Switzerland: World Health Organization

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• To determine if the prevalence of schistosomiasis in children aged 9-12 years is associated with the prevalence in 5-8-year-olds and adults after preventive chemotherapy in schools or the community. We combined data from four community-randomized, preventive chemotherapy trials in treatment-naïve populations in Côte d'Ivoire, Kenya and the United Republic of Tanzania during 2010-2016 according to the number of praziquantel treatments and the delivery method. infection was sought on two slides prepared from each participant's first stool using the Kato-Katz technique. We assessed associations between prevalence in 9-12-year-olds and 5-8-year-olds and adults in the community before and after treatment using Bayesian regression models. Stool samples from 47 985 5-8-year-olds, 81 077 9-12-year-olds and 20 492 adults were analysed. We found associations between the prevalence in 9-12-year-olds and that in 5-8-year-olds and adults after preventive treatment, even when only school-age children were treated. When the prevalence in 9-12-year-olds was under 10%, the prevalence in 5-8-year-olds was consistently under 10%. When the prevalence in 9-12-year-olds was under 50%, the prevalence in adults after two or four rounds of preventive chemotherapy was 10%-15% lower than before chemotherapy. Post-chemotherapy age-group associations were consistent with pre-chemotherapy associations in this analysis and previous studies. The prevalence of infection in 9-12-year-olds was associated with the prevalence in other age groups and could be used to guide community treatment decisions.