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Burden of Clostridium difficile Infection in the United States
Ist Teil von
The New England journal of medicine, 2015-02, Vol.372 (9), p.825-834
Ort / Verlag
United States: Massachusetts Medical Society
Erscheinungsjahr
2015
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
Clostridium difficile
is an important cause of hospital-associated diarrhea. In this report from the CDC, the U.S. burden of
C. difficile
infection is estimated at nearly 500,000 cases and 30,000 deaths in 2011, with an increasing burden among nonhospitalized persons.
Changes in the epidemiology of
Clostridium difficile
infections have occurred since the emergence of the North American pulsed-field gel electrophoresis type 1 (NAP1) strain, which has been responsible for geographically dispersed hospital-associated outbreaks.
1
–
3
In the United States, hospitalizations for
C. difficile
infection among nonpregnant adults doubled from 2000 through 2010 and were projected to continue to increase in 2011 and 2012, especially as laboratories transition to more sensitive
C. difficile
assays, such as the nucleic acid amplification test (NAAT).
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–
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On the basis of data from U.S. death certificates,
C. difficile
infection is the leading cause of gastroenteritis-associated death . . .