Details

Autor(en) / Beteiligte

• Lessa, Fernanda C
• Mu, Yi
• Bamberg, Wendy M
• Beldavs, Zintars G
• Dumyati, Ghinwa K
• Dunn, John R
• Farley, Monica M
• Holzbauer, Stacy M
• Meek, James I
• Phipps, Erin C
• Wilson, Lucy E
• Winston, Lisa G
• Cohen, Jessica A
• Limbago, Brandi M
• Fridkin, Scott K
• Gerding, Dale N
• McDonald, L. Clifford

Titel

Burden of Clostridium difficile Infection in the United States

Ist Teil von

• The New England journal of medicine, 2015-02, Vol.372 (9), p.825-834

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Clostridium difficile is an important cause of hospital-associated diarrhea. In this report from the CDC, the U.S. burden of C. difficile infection is estimated at nearly 500,000 cases and 30,000 deaths in 2011, with an increasing burden among nonhospitalized persons. Changes in the epidemiology of Clostridium difficile infections have occurred since the emergence of the North American pulsed-field gel electrophoresis type 1 (NAP1) strain, which has been responsible for geographically dispersed hospital-associated outbreaks. 1 – 3 In the United States, hospitalizations for C. difficile infection among nonpregnant adults doubled from 2000 through 2010 and were projected to continue to increase in 2011 and 2012, especially as laboratories transition to more sensitive C. difficile assays, such as the nucleic acid amplification test (NAAT). 4 – 6 On the basis of data from U.S. death certificates, C. difficile infection is the leading cause of gastroenteritis-associated death . . .