Virologica Sinica, 2024-02, Vol.39 (1), p.1-8
2024
Details
- Autor(en) / Beteiligte
- Titel
- Single-cell RNA sequencing to understand host-virus interactions
- Ist Teil von
- Virologica Sinica, 2024-02, Vol.39 (1), p.1-8
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2024
- Link zum Volltext
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Single-cell RNA sequencing (scRNA-seq) has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell resolution. This review summarizes the existing scRNA-seq technologies together with their strengths and weaknesses. The applications of scRNA-seq in various virological studies are discussed in depth, which broaden the understanding of the immune atlas, host-virus interactions, and immune repertoire. scRNA-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies. •The existing scRNA-seq technologies together with their strengths and weaknesses are summarized.•Applications of scRNA-seq in SARS-CoV-2 and flavivirus studies are extensively discussed.•Applications of scRNA-seq in studying immune atlas, host-virus interactions, and immune repertoire are further explored.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1995-820X, 1674-0769eISSN: 1995-820XDOI: 10.1016/j.virs.2023.11.009Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10877424
- Format
- –
- Schlagworte
- Bar codes, Biomedical research, Cells, COVID-19, Flavivirus, Gene expression, Gene Expression Profiling, Genomes, Host Microbial Interactions - genetics, Host-virus interaction, Pathogenesis, Research methodology, Review, RNA viruses, Sequence Analysis, RNA, Severe acute respiratory syndrome coronavirus 2, Single-cell RNA sequencing (scRNA-seq), Software packages, Viral infections, Virology, Viruses