Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Calorie restriction reduces biomarkers of cellular senescence in humans
Ist Teil von
Aging cell, 2024-02, Vol.23 (2), p.e14038-n/a
Ort / Verlag
England: John Wiley & Sons, Inc
Erscheinungsjahr
2024
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Calorie restriction (CR) with adequate nutrient intake is a potential geroprotective intervention. To advance this concept in humans, we tested the hypothesis that moderate CR in healthy young‐to‐middle‐aged individuals would reduce circulating biomarkers of cellular senescence, a fundamental mechanism of aging and aging‐related conditions. Using plasma specimens from the Comprehensive Assessment of Long‐term Effects of Reducing Intake of Energy (CALERIE™) phase 2 study, we found that CR significantly reduced the concentrations of several senescence biomarkers at 12 and 24 months compared to an ad libitum diet. Using machine learning, changes in biomarker concentrations emerged as important predictors of the change in HOMA‐IR and insulin sensitivity index at 12 and 24 months, and the change in resting metabolic rate residual at 12 months. Finally, using adipose tissue RNA‐sequencing data from a subset of participants, we observed a significant reduction in a senescence‐focused gene set in response to CR at both 12 and 24 months compared to baseline. Our results advance the understanding of the effects of CR in humans and further support a link between cellular senescence and metabolic health.
Using samples from the CALERIE™ study, we demonstrate that calorie restriction (CR) significantly reduced the concentrations of several circulating biomarkers of cellular senescence compared to an ad libitum diet. Changes in biomarker concentrations were important predictors of the change in HOMA‐IR and insulin sensitivity index, and the change in resting metabolic rate residual. Using adipose tissue RNA‐sequencing data from a subset of participants, we also observed a significant reduction in a senescence‐focused gene set in response to CR. Our results advance the understanding of the effects of CR in humans and further support a link between cellular senescence and metabolic health.