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Re-evaluating the suitability of using fluoroquinolones in the treatment of infections in the context of FQ consumption and correlating changes to microorganism resistance levels in EU/EEA countries between 2016 and 2021
Ist Teil von
Naunyn-Schmiedeberg's archives of pharmacology, 2024-02, Vol.397 (2), p.795-805
Ort / Verlag
Berlin/Heidelberg: Springer Berlin Heidelberg
Erscheinungsjahr
2024
Quelle
MEDLINE
Beschreibungen/Notizen
The aim of this study was to re-evaluate fluoroquinolone (FQ) use in treatment by analyzing the consumption of FQ and the resistance levels of selected Gram‑negative bacilli, as well as
Neisseria gonorrhoeae
and
Mycobacterium tuberculosis complex
in EU/EEA countries and in Poland between 2016 and 2021. Data from ECDC surveillance systems EARS-Net, Euro-GASP, and the European Tuberculosis Surveillance Network were included in the description of pathogen resistance. And the ESAC-Net project for determining FQ consumption. In over half of the EU/EEA countries, the consumption of fluoroquinolones decreased in both the community sector and the hospital sector between 2016 and 2021. The prevalence of FQ-R
Escherichia coli
,
Klebsiella pneumoniae
,
Acinetobacter
spp.,
Mycobacterium tuberculosis complex
, and
Neisseria gonorrhoeae
exceeded 20%. The prevalence of fluoroquinolone-resistant (FQ-R)
Pseudomonas aeruginosa
in EU/EEA countries was less than 20% except for 2017. In most EU/EEA countries, the use of FQ has reduced in last years, except for countries like Poland where FQ were an overused group of antibiotics in the treatment of various types of infections. Fluoroquinolones, as life-saving antibiotics in severe infections, should be withdrawn from empirical treatment in Poland and in countries with a high prevalence of FQ-R microorganisms.