Details

Autor(en) / Beteiligte

• Yang, Wei
• Zhang, Chen
• Liu, Li-Bo
• Bian, Zhan-Zhan
• Chang, Jia-Tong
• Fan, Dong-Ying
• Gao, Na
• Wang, Pei-Gang
• An, Jing

Titel

Immunocompetent mouse models revealed that S100A4 + monocytes/macrophages facilitate long-term Zika virus infection in the testes

Ist Teil von

• Emerging microbes & infections, 2024-12, Vol.13 (1), p.2300466-2300466

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• During its global epidemic, Zika virus (ZIKV) attracted widespread attention due to its link with various severe neurological symptoms and potential harm to male fertility. However, the understanding of how ZIKV invades and persists in the male reproductive system is limited due to the lack of immunocompetent small animal models. In this study, immunocompetent murine models were generated by using anti-IFNAR antibody blocked C57BL/6 male mice and human STAT2 (hSTAT2) knock in (KI) male mice. After infection, viral RNA could persist in the testes even after the disappearance of viremia. We also found a population of ZIKV-susceptible S100A4 monocytes/macrophages that were recruited into testes from peripheral blood and played a crucial role for ZIKV infection in the testis. By using single-cell RNA sequencing, we also proved that S100A4 monocytes/macrophages had a great impact on the microenvironment of ZIKV-infected testes, thus promoting ZIKV-induced testicular lesions. In conclusion, this study proposed a novel mechanism of long-term ZIKV infection in the male reproductive system.