Details

Autor(en) / Beteiligte

• Bunprajun, Tipwadee
• Yuajit, Chaowalit
• Noitem, Rattikarn
• Chatsudthipong, Varanuj

Titel

Exhaustive exercise decreases renal organic anion transporter 3 function

Ist Teil von

• The journal of physiological sciences, 2019-03, Vol.69 (2), p.245-251

Ort / Verlag

Japan: Springer

Erscheinungsjahr

2019

Link zum Volltext

Quelle

SpringerLink (Online service)

Beschreibungen/Notizen

• This study aimed to investigate the effects of various types of exercise on organic anion transporter 3 (Oat3) function, a major transporter that plays a role in the secretion of a variety of drugs and endogenous compounds. Male Wistar rats were randomly allocated to non-exercise, exhaustive, acute and training exercise groups. The function of Oat3 was assessed by the uptake of [ H]-estrone sulfate ([ H]-ES) into rat renal cortical slices. Acute and training exercises had no effect on [ H]-ES uptake whereas a marked reduction in [ H]-ES uptake occurred immediately after exhaustive exercise. However, the reduction in Oat3 function was gradually recovered at 6 and 24 h after the exercise session. Importantly, the impairment of Oat3 function was associated with a decrease in renal Oat3 protein expression. Our results indicate that exhaustive exercise produces a significant impact on renal organic anion transport function, which in turn could alter the plasma level of drugs and compounds in the body.