Details

Autor(en) / Beteiligte

• Garzon-González, Luz Nélida
• Padilla, Laura Tatiana
• Patiño, Felipe
• Hernández, María Alejandra
• Valero, Juan
• Molina, Iván Dario
• Ávila, Fernando Fierro
• Camacho-Moreno, German

Titel

Association between bacterial resistance profile and the development of intra-abdominal abscesses in pediatric patients with perforated appendicitis: cohort study

Ist Teil von

• Pediatric surgery international, 2023-12, Vol.40 (1), p.18-18, Article 18

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Purpose The objective of this study was to determine the association between the presence of a microorganism resistant to the antibiotic used in empirical therapy and the development of intra-abdominal abscesses in children with perforated appendicitis. Methods A prospective cohort study was conducted in patients under 18 years of age who underwent laparoscopic appendectomy between November 1, 2019, and September 30, 2020, in whom perforated appendicitis was documented intraoperatively. Peritoneal fluid samples were taken for bacteria culture purposes, and clinical and microbiological data were collected from all patients. Results A total of 232 patients were included in the study. The most isolated microorganisms were Escherichia coli ( 80.14% ) and Pseudomonas aeruginosa (7.45%). In addition, 5.31% of E. coli isolates were classified as ESBL-producing organisms. No association was found between a germ resistant to empiric antimicrobial therapy and the development of a postoperative intra-abdominal abscess. Multivariate analysis showed that being a high-risk patient on admission (OR 2.89 ( p  = 0.01)) was associated with the development of intra-abdominal abscesses postoperatively. Conclusion E. coli was the most commonly isolated microorganism, with a low rate of ESBL-producing isolates. No association between resistance and risk of postoperative intra-abdominal abscess was found. However, it was identified that being a high-risk patient on admission was associated with this complication. Type of study Prognosis study. Level of evidence Level I.