Details

Autor(en) / Beteiligte

• Zlatanova, Ivana
• Sun, Fei
• Wu, Roland S
• Chen, Xiaoxin
• Lau, Bryan H
• Colombier, Pauline
• Sinha, Tanvi
• Celona, Barbara
• Xu, Shan-Mei
• Materna, Stefan C
• Huang, Guo N
• Black, Brian L

Titel

An injury-responsive mmp14b enhancer is required for heart regeneration

Ist Teil von

• Science advances, 2023-12, Vol.9 (48), p.eadh5313-eadh5313

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Mammals have limited capacity for heart regeneration, whereas zebrafish have extraordinary regeneration abilities. During zebrafish heart regeneration, endothelial cells promote cardiomyocyte cell cycle reentry and myocardial repair, but the mechanisms responsible for promoting an injury microenvironment conducive to regeneration remain incompletely defined. Here, we identify the matrix metalloproteinase Mmp14b as an essential regulator of heart regeneration. We identify a TEAD-dependent endothelial enhancer induced by heart injury in zebrafish and mice, and we show that the enhancer is required for regeneration, supporting a role for Hippo signaling upstream of . Last, we show that MMP-14 function in mice is important for the accumulation of Agrin, an essential regulator of neonatal mouse heart regeneration. These findings reveal mechanisms for extracellular matrix remodeling that promote heart regeneration.