Details

Autor(en) / Beteiligte

• TASAKI, TAKASHI
• SHIBA, EISUKE
• NOGUCHI, HIROTSUGU
• KIRISHIMA, MARI
• KITAZONO, IKUMI
• TERABARU, WATARU
• TABATA, KAZUHIRO
• HIGASHI, MICHIYO
• SHINOHARA, NAOHIRO
• SASAKI, HIROMI
• NAKAJO, MASANORI
• NAKAJO, MASATOYO
• HISAOKA, MASANORI
• TANIMOTO, AKIHIDE

Titel

Low-grade Fibromyxoid Sarcoma With Massive Degeneration: A Case of Unusual Gross and Histological Features

Ist Teil von

• In vivo (Athens), 2023-11, Vol.37 (6), p.2863-2868

Ort / Verlag

International Institute of Anticancer Research

Erscheinungsjahr

2023

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• BACKGROUNDLow-grade fibromyxoid sarcoma (LGFMS) is a rare type of sarcoma which is observed in the soft tissue of proximal extremities, typically in young and middle-aged adults. It consists of a solid proliferation of bland spindle cells within collagenous and myxoid stroma.CASE REPORTHerein, we report a case of LGFMS with massive degeneration and hyalinization. A 30-year-old man presented with a well-circumscribed mass measuring 15 cm in diameter in his left biceps femoris muscle. Marginal tumor resection was performed under the clinical diagnosis of an ancient schwannoma or chronic expanding hematoma (CEH). The resected tissue revealed a well-demarcated tumor mass with massive degeneration and hyalinization with focal calcification. Proliferation of spindle tumor cells with abundant collagenous stroma, which resembled the fibrous capsule of CEH, was observed exclusively in a small area of the periphery of the tumor. No nuclear palisading, myxoid stroma, or collagen rosettes were identified. Immunohistochemical analysis demonstrated that the spindle tumor cells expressed mucin 4 and epithelial membrane antigen. Reverse transcriptase-polymerase chain reaction analysis detected mRNA expression of fused in sarcoma::CAMP-responsive element binding protein 3-like protein 2 (FUS::CREB3L2) fusion gene. Thus, a final diagnosis of LGFMS with massive degeneration and FUS::CREB3L2 fusion was made.CONCLUSIONThe recognition of massive degeneration and hyalinization as unusual features of LGFMS might be helpful to differentiate it from CEH and other benign spindle-cell tumors.