Details

Autor(en) / Beteiligte

• Dumm, Will
• Barker, Mary
• Howard-Snyder, William
• DeWitt III, William S.
• Matsen IV, Frederick A.

Titel

Representing and extending ensembles of parsimonious evolutionary histories with a directed acyclic graph

Ist Teil von

• Journal of mathematical biology, 2023-11, Vol.87 (5), p.75-75, Article 75

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• In many situations, it would be useful to know not just the best phylogenetic tree for a given data set, but the collection of high-quality trees. This goal is typically addressed using Bayesian techniques, however, current Bayesian methods do not scale to large data sets. Furthermore, for large data sets with relatively low signal one cannot even store every good tree individually, especially when the trees are required to be bifurcating. In this paper, we develop a novel object called the “history subpartition directed acyclic graph” (or “history sDAG” for short) that compactly represents an ensemble of trees with labels (e.g. ancestral sequences) mapped onto the internal nodes. The history sDAG can be built efficiently and can also be efficiently trimmed to only represent maximally parsimonious trees. We show that the history sDAG allows us to find many additional equally parsimonious trees, extending combinatorially beyond the ensemble used to construct it. We argue that this object could be useful as the “skeleton” of a more complete uncertainty quantification.