Details

Autor(en) / Beteiligte

• Xie, Jianling
• Kuppermann, Nathan
• Florin, Todd A
• Tancredi, Daniel J
• Funk, Anna L
• Kim, Kelly
• Salvadori, Marina I
• Yock-Corrales, Adriana
• Shah, Nipam P
• Breslin, Kristen A
• Chaudhari, Pradip P
• Bergmann, Kelly R
• Ahmad, Fahd A
• Nebhrajani, Jasmine R
• Mintegi, Santiago
• Gangoiti, Iker
• Plint, Amy C
• Avva, Usha R
• Gardiner, Michael A
• Malley, Richard
• Finkelstein, Yaron
• Dalziel, Stuart R
• Bhatt, Maala
• Kannikeswaran, Nirupama
• Caperell, Kerry
• Campos, Carmen
• Sabhaney, Vikram J
• Chong, Shu-Ling
• Lunoe, Maren M
• Rogers, Alexander J
• Becker, Sarah M
• Borland, Meredith L
• Sartori, Laura F
• Pavlicich, Viviana
• Rino, Pedro B
• Morrison, Andrea K
• Neuman, Mark I
• Poonai, Naveen
• Simon, Norma-Jean E
• Kam, April J
• Kwok, Maria Y
• Morris, Claudia R
• Palumbo, Laura
• Ambroggio, Lilliam
• Navanandan, Nidhya
• Eckerle, Michelle
• Klassen, Terry P
• Payne, Daniel C
• Cherry, Jonathan C
• Waseem, Muhammad
• Dixon, Andrew C
• Ferre, Isabel Beneyto
• Freedman, Stephen B

Titel

Impact of SARS-CoV-2 Infection on the Association Between Laboratory Tests and Severe Outcomes Among Hospitalized Children

Ist Teil von

• Open forum infectious diseases, 2023-10, Vol.10 (10), p.ofad485-ofad485

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Background To assist clinicians with identifying children at risk of severe outcomes, we assessed the association between laboratory findings and severe outcomes among severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–infected children and determined if SARS-CoV-2 test result status modified the associations. Methods We conducted a cross-sectional analysis of participants tested for SARS-CoV-2 infection in 41 pediatric emergency departments in 10 countries. Participants were hospitalized, had laboratory testing performed, and completed 14-day follow-up. The primary objective was to assess the associations between laboratory findings and severe outcomes. The secondary objective was to determine if the SARS-CoV-2 test result modified the associations. Results We included 1817 participants; 522 (28.7%) SARS-CoV-2 test-positive and 1295 (71.3%) test-negative. Seventy-five (14.4%) test-positive and 174 (13.4%) test-negative children experienced severe outcomes. In regression analysis, we found that among SARS-CoV-2-positive children, procalcitonin ≥0.5 ng/mL (adjusted odds ratio [aOR], 9.14; 95% CI, 2.90–28.80), ferritin >500 ng/mL (aOR, 7.95; 95% CI, 1.89–33.44), D-dimer ≥1500 ng/mL (aOR, 4.57; 95% CI, 1.12–18.68), serum glucose ≥120 mg/dL (aOR, 2.01; 95% CI, 1.06–3.81), lymphocyte count <1.0 × 109/L (aOR, 3.21; 95% CI, 1.34–7.69), and platelet count <150 × 109/L (aOR, 2.82; 95% CI, 1.31–6.07) were associated with severe outcomes. Evaluation of the interaction term revealed that a positive SARS-CoV-2 result increased the associations with severe outcomes for elevated procalcitonin, C-reactive protein (CRP), D-dimer, and for reduced lymphocyte and platelet counts. Conclusions Specific laboratory parameters are associated with severe outcomes in SARS-CoV-2-infected children, and elevated serum procalcitonin, CRP, and D-dimer and low absolute lymphocyte and platelet counts were more strongly associated with severe outcomes in children testing positive compared with those testing negative.