Details

Autor(en) / Beteiligte

• Wang, Yu
• Pu, Xuehua
• Zhu, Zhiyun
• Sun, Wenbin
• Xue, Lu
• Ye, Jilu

Titel

Handgrip strength and the prognosis of patients with heart failure: A meta-analysis

Ist Teil von

• Clinical cardiology (Mahwah, N.J.), 2023-10, Vol.46 (10), p.1173-1184

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Quelle

Wiley Online Library

Beschreibungen/Notizen

• Reduced muscular strength is common in patients with heart failure (HF). The aim of the systematic review and meta-analysis was to evaluate the association between handgrip strength (HGS) and prognosis of patients with HF. Reduced HGS may be a risk factor of poor prognosis of patients with HF. Relevant observational studies with longitudinal follow-up were obtained by a comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science databases. A random-effects model was used to pool the results. Fifteen studies involving 7350 patients with HF were included in the meta-analysis. Pooled results showed that HF patients with lower HGS were associated with a higher risk of mortality during follow-up (risk ratio [RR]: 2.00, 95% confidence interval [CI]: 1.55-2.58, p < .001; I  = 0%). Subgroup analysis showed that the association was not significantly affected by characteristics such as study country, design, mean age of the patients, HF status (stable or advanced/acute), HF type (reduced or preserved ejection fraction), follow-up duration, and quality score (p for subgroup difference all > 0.05). Further analysis showed that per 1 kgf decrease of HGS was associated with an 8% increased risk of mortality during follow-up (RR: 1.08, 95% CI: 1.05-1.11, p < .001; I  = 12%). Moreover, HF patients with lower HGS were also related to a higher risk of composite outcome of HF rehospitalization or mortality (RR: 1.67, 95% CI: 1.19-2.35, p = .003; I  = 53%). A low HGS may be associated with poor clinical outcomes of patients with HF.