Details

Autor(en) / Beteiligte

• Gupta, Prachi Mehrotra
• Balle, Christina
• Tharp, Gregory K.
• Nelson, Sydney A.
• Gasper, Melanie A.
• Brown, Bryan
• Alisoltani, Arghavan
• Onono, Maricianah
• Palanee-Phillips, Thesla
• Nair, Gonsagrie
• Ayele, Hosseana
• Noel-Romas, Laura
• Passmore, Jo-Ann S.
• Burgener, Adam D.
• Heffron, Renee
• Jaspan, Heather B.
• Bosinger, Steven E.

Titel

Systems analysis reveals differential expression of endocervical genes in African women randomized to DMPA-IM, LNG implant or cu-IUD

Ist Teil von

• Clinical immunology (Orlando, Fla.), 2023-10, Vol.255, p.109750-109750, Article 109750

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Although effective contraceptives are crucial for preventing unintended pregnancies, evidence suggests that their use may perturb the female genital tract (FGT). A comparative analysis of the effects of the most common contraceptives on the FGT have not been evaluated in a randomized clinical trial setting. Here, we evaluated the effect of three long-acting contraceptive methods: depot medroxyprogesterone acetate(DMPA-IM), levonorgestrel(LNG) implant, and a copper intrauterine device (Cu-IUD), on the endocervical host transcriptome in 188 women from the Evidence for Contraceptive Options and HIV Outcomes Trial (ECHO) trial. Cu-IUD usage showed the most extensive transcriptomic changes, and was associated with inflammatory and anti-viral host responses. DMPA-IM usage was enriched for pathways associated with T cell responses. LNG implant had the mildest effect on endocervical gene expression, and was associated with growth factor signaling. These data provide a mechanistic basis for the diverse influence that varying contraceptives have on the FGT. [Display omitted] •Contraceptives significantly impact the immune system of the female genital tract (FGT)•The impact of DMPA, LNG implant, and Cu-IUD on the FGT was studied in 188 women from the ECHO trial using functional genomics•Cu-IUD led to elevated metallothionein responses associated with increased inflammation•DMPA usage was associated with enhanced T cell recruitment and signaling•LNG implant had the mildest impact on the FGT environment