Details

Autor(en) / Beteiligte

• Wilbers, René
• Metodieva, Verjinia D
• Duverdin, Sarah
• Heyer, Djai B
• Galakhova, Anna A
• Mertens, Eline J
• Versluis, Tamara D
• Baayen, Johannes C
• Idema, Sander
• Noske, David P
• Verburg, Niels
• Willemse, Ronald B
• de Witt Hamer, Philip C
• Kole, Maarten H P
• de Kock, Christiaan P J
• Mansvelder, Huibert D
• Goriounova, Natalia A

Titel

Human voltage-gated Na + and K + channel properties underlie sustained fast AP signaling

Ist Teil von

• Science advances, 2023-10, Vol.9 (41), p.eade3300-eade3300

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Human cortical pyramidal neurons are large, have extensive dendritic trees, and yet have unexpectedly fast input-output properties: Rapid subthreshold synaptic membrane potential changes are reliably encoded in timing of action potentials (APs). Here, we tested whether biophysical properties of voltage-gated sodium (Na ) and potassium (K ) currents in human pyramidal neurons can explain their fast input-output properties. Human Na and K currents exhibited more depolarized voltage dependence, slower inactivation, and faster recovery from inactivation compared with their mouse counterparts. Computational modeling showed that despite lower Na channel densities in human neurons, the biophysical properties of Na channels resulted in higher channel availability and contributed to fast AP kinetics stability. Last, human Na channel properties also resulted in a larger dynamic range for encoding of subthreshold membrane potential changes. Thus, biophysical adaptations of voltage-gated Na and K channels enable fast input-output properties of large human pyramidal neurons.