Details

Autor(en) / Beteiligte

• Satter, Syed M
• Abdullah, Zarin
• Fariha, Farzana
• Karim, Yeasir
• Rahman, Md Mahfuzur
• Balachandran, Neha
• Ghosh, Probir Kumar
• Hossain, Mohammad Enayet
• Mirza, Sara A
• Hall, Aron J
• Gastañaduy, Paul A
• Rahman, Mustafizur
• Vinjé, Jan
• Parashar, Umesh D

Titel

Epidemiology and Risk Factors of Norovirus Infections Among Diarrhea Patients Admitted to Tertiary Care Hospitals in Bangladesh

Ist Teil von

• The Journal of infectious diseases, 2023-10, Vol.228 (7), p.818-828

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2023

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background Norovirus is a major cause of endemic acute gastroenteritis (AGE) worldwide. We described the epidemiology, risk factors, and genotypic distribution of noroviruses among hospitalized patients of all ages in Bangladesh. Methods From March 2018 to October 2021, 1250 AGE case patients and controls (age, sex, season, and site matched) were enrolled at 10 hospitals. Demographic and clinical information was collected; real-time reverse-transcriptase polymerase chain reaction (RT-PCR) used to test stool specimens, and positive samples were genotyped. Results Norovirus was detected in 9% of cases (111 of 1250) and 15% (182 of 1250) of controls. Eighty-two percent of norovirus-positive cases were in children <5 years old. Norovirus-positive AGE hospitalizations occurred year-round, with peaks in April and October. Risk factors for norovirus included age <5 years (adjusted odds ratio, 3.1 [95% confidence interval, 1.9–5.2]) and exposure to a patient with AGE in the 10 days before enrollment (3.8 [1.9–7.2]). GII.3[P16] and GII.4 Sydney[P16] were the predominant genotypes. Conclusions We highlight the burden of norovirus in hospital settings. Young age and recent exposure to a patient with AGE were risk factors for norovirus. A high prevalence of norovirus among controls might represent asymptomatic reinfections or prolonged shedding from a previous infection; carefully designed longitudinal studies are needed to improve our understanding of norovirus infections in Bangladesh. We studied the epidemiology, risk factors, and genetic distribution of noroviruses among hospitalized patients of all ages. 9% of AGE cases and 15% of controls were norovirus positive; young age and recent AGE exposure increased the risk of infection.