Details

Autor(en) / Beteiligte

• Dua, Damneek
• Stubbs, Oliver
• Urasa, Sarah
• Rogathe, Jane
• Duijinmaijer, Ashanti
• Howlett, William
• Dekker, Marieke
• Kisoli, Aloyce
• Mukaetova-Ladinska, Elizabeta B.
• Gray, William K.
• Lewis, Thomas
• Walker, Richard W.
• Dotchin, Catherine L.
• Lwezuala, Bingileki
• Makupa, Philip C.
• Paddick, Stella Maria

Titel

The prevalence and outcomes of depression in older HIV-positive adults in Northern Tanzania: a longitudinal study

Ist Teil von

• Journal of neurovirology, 2023-08, Vol.29 (4), p.425-439

Ort / Verlag

Cham: Springer International Publishing

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa. This study aims to investigate the prevalence of psychiatric disorders in PLWH aged ≥ 50 years in Tanzania focussing on prevalence and 2-year outcomes of depression. PLWH aged ≥ 50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric Interview (MINI). Neurological and functional impairment was assessed at year 2 follow-up. At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up ( n  = 162), incident cases of DSM-IV depression decreased from14.2 to 11.1% (χ 2 : 2.48, p  = 0.29); this decline was not significant. Baseline depression was associated with increased functional and neurological impairment. At follow-up, depression was associated with negative life events ( p  = 0.001), neurological impairment ( p  < 0.001), and increased functional impairment ( p  = 0.018), but not with HIV and sociodemographic factors. In this setting, depression appears highly prevalent and associated with poorer neurological and functional outcomes and negative life events. Depression may be a future intervention target.