Details

Autor(en) / Beteiligte

• Nagot, Nicolas
• Binh, Nguyen Thanh
• Hong, Tran Thi
• Vinh, Vu Hai
• Quillet, Catherine
• Huong, Duong Thi
• Hai Oanh, Khuat Thi
• Thanh, Nham Thi Tuyet
• Rapoud, Delphine
• Quynh, Bach Thi Nhu
• Feelemyer, Jonathan
• Michel, Laurent
• Vickerman, Peter
• Fraser, Hannah
• Weiss, Laurence
• Lemoine, Maud
• Lacombe, Karine
• Moles, Jean Pierre
• Laureillard, Didier
• Jarlais, Don Des
• Vallo, Roselyne
• Moles, Jean-Pierre
• Khue, Pham Minh
• Thanh Hang, Nguyen Thi
• Hai, Phung Quang
• Duc, Cap Minh
• Nhu Quynh, Bach Thi
• Linh, Le Thuy
• Thi hong, Nguyen
• Thu Trang, Vu Thi
• Thanh Huong, Nguyen Thi
• Thia, Hoang Thi
• Hai Binh, Doan Thi
• Van Luc, Nguyen
• Thu Ha, Vu Thi
• Nhung, Do Thi
• Khoi, Bui Minh
• Thien, Bui Thi
• Vu Quang, La Thi
• Toi, Le Huu
• Thanh Phuong, Pham Thi
• Lieu, Pham Thi
• Thanh Mai, Pham Thi
• Hoa, Trinh Thi
• Thu Ha, Nguyen Thi
• Xuyen, Nguyen Thi
• Thi Duyen, Tran
• Que, Vu Thi
• Dung, Nguyen Duc
• Tuan, Nguyen Duc
• Hung, Nguyen Manh
• Van Tu, Vu
• Kien, Nguyen Thanh
• Thu Hong, Pham Thi
• Cuc, Truong Thi
• Lan, Nguyen Thi
• Va, Nguyen Thi
• Van Cuong, Doan
• Van Hoan, Pham
• Hiep, Ha Quang
• Ninh, Ngo Trong
• Quan, Nguyen Anh
• Bich Hop, Vu Thi
• Thu, Nguyen Thi
• Sau, Nguyen Thi
• Van Tuan, Hoang
• Nhan, Nguyen Huu
• Tuan, Nguyen Quoc
• Long, Le Tuan
• Son, Vu Minh
• Hoc, Tran Viet
• Van Dinh, Nguyen
• Hoang, Nguyen
• Hung, Pham Thi
• Binh, Trinh Thai
• Hang, Le Thi
• Quan, Hoang Dang
• Thi Thanh, Nguyen
• Cuong, La Cao
• Van Ha, Tran
• Van Thao, Tran
• Truong, Nguyen Xuan
• Hanh, Nguyen Duc
• Lien, Tran Thi
• Tuyet Thanh, Nham Thi
• Thuy Linh, Bui Thi
• Dien, Ngo Thi
• Trickey, Adam

Titel

A community-based strategy to eliminate hepatitis C among people who inject drugs in Vietnam

Ist Teil von

• The Lancet regional health. Western Pacific, 2023-08, Vol.37, p.100801-100801, Article 100801

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Towards hepatitis C elimination among people who inject drugs (PWID), we assessed the effectiveness of a strategy consisting of a community-based respondent-driven sampling (RDS) as wide screening, a simplified and integrated hospital-based care, and prevention of reinfection supported by community-based organisations (CBO), in Hai Phong, Vietnam. Adults who injected heroin were enrolled in a RDS survey implemented in two CBO premises. Rapid HIV and HCV tests were done on site, and blood was taken for HCV RNA testing. Those with detectable HCV RNA were referred with CBO support to three public hospitals for 12-week sofosbuvir/daclatasvir, plus ribavirin for patients with cirrhosis. Participants were followed-up 12 weeks post-treatment (SVR12) and 48 weeks after enrolment. The primary endpoint was the rate of undetectable HCV RNA participants at 48 weeks. Among the 1444 RDS survey participants, 875 had hepatitis C. Their median age was 41 years (IQR 36–47), 96% were males, 36% were HIV-coinfected. Overall, 686 (78.4%) started sofosbuvir/daclatasvirs, and 629 of the 647 (97.2%) patients tested at SVR12 were cured. At week 48 (581/608) 95.6% had undetectable HCV RNA, representing 66.4% of all PWID identified with hepatitis C. The reinfection rate after SVR12 was 4/100 person-years (95% CI: 2–7). Our strategy, involving CBO and addressing all steps from wide HCV screening to prevention of reinfection, stands as a promising approach to eliminate HCV among PWID in low and middle-income countries. France ANRS|MIE (#ANRS12380). The RDS survey was implemented with grants from the NIDA (#R01DA041978) and ANRS|MIE (#ANRS12353).