Details

Autor(en) / Beteiligte

• Redman, Jason M
• O’Sullivan Coyne, Geraldine
• Reed, Clay T
• Madan, Ravi A
• Strauss, Julius
• Steinberg, Seth J
• Marté, Jennifer
• Cordes, Lisa
• Heery, Christopher
• Gulley, James L

Titel

Avelumab in Patients With Metastatic Colorectal Cancer

Ist Teil von

• The oncologist (Dayton, Ohio), 2023-09, Vol.28 (9), p.823-e804

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Abstract Background Metastatic colorectal cancer (mCRC) is incurable, and median overall survival is less than 2½ years. Although monoclonal antibodies that block PD-1/PD-L1 interactions are active in microsatellite unstable/mismatch repair deficient tumors, a growing dataset shows that most patients with microsatellite stable/mismatch repair proficient tumors will not benefit from the blockade of PD-1/PD-L1 interactions. Here we present results from patients with mCRC (n = 22) treated with the anti-PD-L1 monoclonal antibody avelumab. Methods Patients received treatment on a phase I, open-label, dose-escalation trial via a consecutive parallel-group expansion in colorectal cancer. Patients aged 18 years and older with mCRC measurable by RECIST v1.1 who had received at least 1 line of systemic therapy for metastatic disease enrolled. Patients with prior immune checkpoint inhibitor treatment were excluded. Patients received avelumab 10 mg/kg intravenously every 2 weeks. The primary endpoint was the objective response rate. Results Twenty-two participants received treatment from July 2013 to August 2014. There were no objective responses and median progression-free survival was 2.1 months (95% CI: 1.4-5.5 months). There were 5 grade 3 treatment-related adverse events: GGT elevation (n = 2), PRESS (n = 1), lymphopenia (n = 1), and asymptomatic amylase/lipase elevation (n = 1). Conclusion As demonstrated with other anti-PD-1/PD-L1 monoclonal antibodies, avelumab is not active in unselected patients with mCRC (ClinicalTrials.gov Identifier: NCT01772004). Effective treatment options for patients with metastatic colorectal cancer are limited, following progression on first- and second-line chemotherapy-based regimens. The results of this study add to a growing dataset showing that therapeutic blockade of PD-1/PD-L1 interactions is not sufficient to facilitate significant immune-mediated antitumor activity in this population.