Details

Autor(en) / Beteiligte

• Jansen, Philip
• Nakanishi, Tomoko
• Priest, James
• Turebayeva, Gulsimzhan
• Bouab, Meriem
• Bourque, Guillaume
• Tse, Sze Man
• Faucon, Annika B
• Jensen, Björn-Erik Ole
• Bals, Robert
• Noor, Abdul
• Liontos, Angelos
• Azuure, Clinton
• Blanco-Grau, Albert
• Casalone, Elisabetta
• Bellelli, Giuseppe
• Kurihara, Hayato
• Farré, Xavier
• Hunkapiller, Julie
• Kim, Jin Yong
• Lee, Ji Yeon
• Jung, Keum Ji
• Bretherick, Andrew D
• Ostermann, Marlies
• Ryan, Lucy
• Briton, Kate
• Cutler, Sean
• Springle, Philippa
• Goodwin, Emma
• Tibke, Clare
• Farley, Sean
• Bradley-Potts, Joanne
• Whileman, Amanda
• Kaye, Callum
• Preston, Stephen
• Cupitt, Jason
• Jakkula, Srinivas
• Lamb, Thomas
• Hudson, Anne
• Clark, Richard
• Hudig, Lisa
• Roberts, Abigail
• Slevin, Kathryn
• Thomas, Vicky
• Chisholm, Catherine
• Scanlon, Jeremy
• Jones, Helen
• Riches, Joanne
• Anderson, Susan
• Davies, Rhys
• Tebbutt, Julie
• Conyngham, Jo-Anna
• Hobden, Gillian
• Collier, Dawn
• Durga, Latha
• Wilson, Alison
• Finnell, Jez
• Serrano-Ruiz, Alfredo
• Turner, Patricia
• Turney, Sharon
• Tutt, Gabriella
• Varghese, Mathew
• Stuart, Carmel
• Wood, Stephen
• Cother, Naiara
• Brady, Ailbhe
• Arden, Tracie
• Capps, Nigel
• Lennon, Liz
• Joseph, Sibet
• Jennings, Claire
• Revill, Adam
• Fletcher, Jo
• Sutherland, Isobel
• Kaye, Duncan
• Whitbread, Jennifer
• Hector, Gemma
• Goddard, Peter
• Lauder, Christen
• Oosthuyzen, Wilna
• Szoor-Mcelhinney, Helen
• Upadhyay, Kamlesh J
• Joshi, Chaitanya G
• Kabata, Hiroki
• Mikami, Yohei
• Sonobe, Kazunari
• Tateno, Hiroki
• Yoshihara, Tomoyuki
• Kuwahara, Naota
• Sugiura, Hisatoshi
• Ishihara, Sayoko
• Ismail, Said I
• Feng, Yen-Chen Anne
• Castano, Luis
• Ceballos, Francisco C
• Aguado, Jose María
• Carbonell, Cristina
• Werge, Thomas
• Wilson, Daniel J
• Serra-Llovich, Alex

Titel

A second update on mapping the human genetic architecture of COVID-19

Ist Teil von

• Nature (London), 2023-09, Vol.621 (7977), p.E7-3

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• In total, 15 out of 51 loci could be linked to three major pathways involved in susceptibility and severity defined by expert-driven classification (Supplementary Note): (1) viral entry; (2) entry defence in airway mucus; and (3) type I interferon response. [...]the phenome-wide association analysis identified nine loci involved in the upkeep of healthy lung tissue. [...]four loci contain candidate causal genes for entry defence in the airway mucus (Extended Data Fig. lb), such as previously reported MUC1/THBS3 (lq22) and MUC5B (lip 15.5) as well as novel MUC4 (3q29) and MUC16 (19pl3.2). [...]the previously reported locus lq22 contains an intergenic lead variant rsl2752585:G>A that decreases the risk of infection (OR = 0.98,95% CI = 0.97-0.98, P = 1.5 x 10_11) and increases MUCI expression in the oesophagus mucosa in GTEx v8 (P=5.2 x 10-9). [...]six loci contain candidate causal genes that are linked to the type I interferon pathway (Extended Data Fig. 1c), such as previously reported IFNAR2 (21q22.11), OAS1 (12q24.13) and TYK2 (19pl3.2), as well as additionally identified JAKI (lp31.3), IRF1 (5q31.1) and IFNa-coding genes (9p21.3).