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If You're Not Confused, You're Not Paying Attention: Ochrobactrum Is Not Brucella
Ist Teil von
Journal of clinical microbiology, 2023-08, Vol.61 (8), p.e0043823-e0043823
Ort / Verlag
United States: American Society for Microbiology
Erscheinungsjahr
2023
Quelle
MEDLINE
Beschreibungen/Notizen
Bacteria of the genus Brucella are facultative intracellular parasites that cause brucellosis, a severe animal and human disease. Recently, a group of taxonomists merged the brucellae with the primarily free-living, phylogenetically related
spp. in the genus Brucella. This change, founded only on global genomic analysis and the fortuitous isolation of some opportunistic
spp. from medically compromised patients, has been automatically included in culture collections and databases. We argue that clinical and environmental microbiologists should not accept this nomenclature, and we advise against its use because (i) it was presented without in-depth phylogenetic analyses and did not consider alternative taxonomic solutions; (ii) it was launched without the input of experts in brucellosis or
; (iii) it applies a non-consensus genus concept that disregards taxonomically relevant differences in structure, physiology, population structure, core-pangenome assemblies, genome structure, genomic traits, clinical features, treatment, prevention, diagnosis, genus description rules, and, above all, pathogenicity; and (iv) placing these two bacterial groups in the same genus creates risks for veterinarians, medical doctors, clinical laboratories, health authorities, and legislators who deal with brucellosis, a disease that is particularly relevant in low- and middle-income countries. Based on all this information, we urge microbiologists, bacterial collections, genomic databases, journals, and public health boards to keep the Brucella and
genera separate to avoid further bewilderment and harm.