Details

Autor(en) / Beteiligte

• Tang, Lin
• Wang, Fu-Zhen
• Rodewald, Lance E
• Wang, Xuan-Yi
• Liu, Si-Yu
• Liu, Qian-Qian
• Wang, Xiao-Qi
• Wu, Dan
• Li, Ming-Shuang
• Zhang, Qian
• Shao, Yi-Ming
• Huang, Li-Fang
• Song, Yu-Dan
• Huang, Yong
• Zeng, Xiang
• Liu, Li-Jun
• Yang, Hong
• Huang, Ao-Di
• Bao, Li-Ming
• Zheng, Hui
• Ma, Chao
• Lv, Xiao-Ya
• Song, Lei
• Ma, Zhao
• Wang, Shu-Guang
• Ma, Hao
• Guan, Wei-Jie
• Wu, Zhi-Yin
• Zhong, Nan-Shan
• Yin, Zun-Dong

Titel

Real-World Effectiveness of Primary Series and Booster Doses of Inactivated Coronavirus Disease 2019 Vaccine Against Omicron BA.2 Variant Infection in China: A Retrospective Cohort Study

Ist Teil von

• The Journal of infectious diseases, 2023-08, Vol.228 (3), p.261-269

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Abstract Background China has been using inactivated coronavirus disease 2019 (COVID-19) vaccines as primary series and booster doses to protect the population from severe to fatal COVID-19. We evaluated primary and booster vaccine effectiveness (VE) against Omicron BA.2 infection outcomes. Methods This was a 13-province retrospective cohort study of quarantined close contacts of BA.2-infected individuals. Outcomes were BA.2 infection, COVID-19 pneumonia or worse, and severe/critical COVID-19. Absolute VE was estimated by comparison with an unvaccinated group. Results There were 289 427 close contacts ≥3 years old exposed to Omicron BA.2 cases; 31 831 turned nucleic acid amplification test–positive during quarantine, 97.2% with mild or asymptomatic infection, 2.6% with COVID-19 pneumonia, and 0.15% with severe/critical COVID-19. None died. Adjusted VE (aVE) against any infection was 17% for primary series and 22% when boosted. Primary series aVE in adults >18 years was 66% against COVID-19 pneumonia or worse and 91% against severe/critical COVID-19. Booster dose aVE was 74% against pneumonia or worse, and 93% against severe/critical COVID-19. Conclusions Inactivated COVID-19 vaccines provided modest protection from infection, very good protection against pneumonia, and excellent protection against severe/critical COVID-19. Booster doses are necessary to provide strongest protection. China-produced inactivated COVID-19 absolute vaccine effectiveness (VE) levels against Omicron BA.2 infection, pneumonia or worse, and severe COVID-19 were 17%, 66%, and 91%; boosted VEs were 22%, 74%, and 93%. Inactivated vaccines were highly effective against severe COVID-19 in China's then infection-naive population.